Induced connective tissue metabolism in vivo: reutilization of pre-existing collagen.
نویسندگان
چکیده
منابع مشابه
Induced connective tissue metabolism in vivo: reutilization of pre-existing collagen.
Light and electron microscopy of resorbing connective tissues have shown that the collagen fibers and fibrils disappear. It is usually presumed that resorbed collagen is degraded proteolytically to hydroxyproline-containing peptides and to free amino acids, including hydroxyproline. We wish to present evidence that collagen can be resorbed and then reutilized without such breakdown. Urinary exc...
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Since it was established that defects in collagen metabolism were associated with inherited connective tissue disease (McKusick, 1972), considerable effort has been put into discovering the molecular basis of these genetic disorders. Up to 5 years ago a link between structural mutations in collagen genes and inherited connective tissue disease was considered likely, but there was little direct ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1966
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.56.1.277